Factory sells Ethyl 4-(1-hydroxy-1-methylethyl)-2-propyl-imidazole-5-carboxylate 144689-93-0 with sufficient production capacity
- Molecular Formula:C12H20N2O3
- Molecular Weight:240.302
- Vapor Pressure:0mmHg at 25°C
- Melting Point:98-100°C
- Refractive Index:1.521
- Boiling Point:456.2 °C at 760 mmHg
- PKA:11.61±0.10(Predicted)
- Flash Point:229.7 °C
- PSA：75.21000
- Density:1.131 g/cm3
- LogP:1.76630
Ethyl 4-(1-hydroxy-1-methylethyl)-2-propyl-imidazole-5-carboxylate(Cas 144689-93-0) Usage
Ethyl 4-(1-hydroxy-1-methylethyl)-2-propyl-imidazole-5-carboxylate is a chemical intermediate used in the production of Olmesartan. It is also known as 2-Propyl-5-(1-hydroxy-1-methylethyl)-3H-imidazole-4-carboxylic Acid Ethyl Ester. Shanghai Wibson Biotechnology Co., Ltd. is a high-tech enterprise that mainly develops and sells pharmaceutical and chemical raw materials and other related products. We have 16 years of experience in R&D and manufacturing, we have rich experience in shipping, many well-known companies have cooperated with us, and are good at shipping various chemical products with us.We can provide OEM,ODM service with low MOQ!
InChI:InChI=1/C12H20N2O3/c1-5-7-8-13-9(11(15)17-6-2)10(14-8)12(3,4)16/h16H,5-7H2,1-4H3,(H,13,14)
144689-93-0 Relevant articles
Identification synthesis of process-related impurities (substances) ethyl-4-(1-hydroxy-1-methylethyl)-2-propyl-imidazole-5-carboxylate [key intermediate of Olmesartan medoxomil (Anti hypertensive drug)]
Venkannaa G.2, Madhusudhan G.1,*, Mukkanti K.2, Kumar Y. Sampath1
Asian Journal of Research in Chemistry, 2015, Volume : 8, Issue : 5
During the preparation of ethyl 4-(1-Hydroxy-1-methylethyl)-2-propylimidazole-5-carboxylate (1), derivative, eleven related substances (Impurities and analog) were observed along with the final Imidazole derivative. Those impurities were identified as, Ethyl carbinol imidazole (13), Methoxy imidazole (14), Olefinic imidazole (15), 4-Acetyl imidazole (12), Diacetyl imidazole (16), 5-Acetyl imidazole (17), Diethyl ester imidazole (9), Acetate imidazole Impurity (23), Propionate imidazole Impurity (29), Isobutyrate Imidazole Impurity (41) and butyl Imidazole Impurity (35). Present work describes the synthesis and characterization of all these elven impurities.
Oxidative treatment of crude pharmaceutical industry effluent by hydrodynamic cavitation
Jitesh Lalwani a , Ashutosh Gupta a , Shashidhar Thatikonda a , Challapalli Subrahmanyam b
Journal of Environmental Chemical Engineering Volume 8, Issue 5 , October 2020, 104281
Wastewater was sampled directly from a pharmaceutical industry based in Hyderabad, India, primarily manufacturing API’s of the ARB class such as olmesartan (C24H26N6O3; molecular mass: 446.5 g/mol) and its intermediates. Olmesartan was produced by the industry by hydrolysis of olmesartan medoxomil (C29H30N6O6; molecular mass: 558.6 g/mol) in two sequential stages, after being initiated by the addition of KSM’s such as ethyl 4-(1-hydroxy-1-methylethyl)-2-propyl-imidazole-5-carboxylate
A 4 - (1 - hydroxy -1 - methyl ethyl) -2 - propyl - 1H - imidazole -5 - carboxylic acid ethyl ester preparation method
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Paragraph 0048; 0049; 0052; 0053, (2017/08/25)
The invention relates to a preparation m...
144689-93-0 Process route
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- 676-58-4
methylmagnesium chloride
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- 144689-94-1
diethyl 2-(n-propyl)-1H-imidazole-4,5-dicarboxylate
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- 144689-93-0
ethyl 4-(2-hydroxypropan-2-yl)-2-propyl-1H-imidazole-5-carboxylate
Conditions
| Conditions |
Yield |
|
methylmagnesium chloride; diethyl 2-(n-propyl)-1H-imidazole-4,5-dicarboxylate; In tetrahydrofuran; at -10 - 0 ℃; for 0.166667h;
With water; ammonium chloride; In tetrahydrofuran; dichloromethane;
|
85% |
|
In tetrahydrofuran; 2-methyltetrahydrofuran; toluene; at 15 ℃; Flow reactor;
|
76.5% |
|
methylmagnesium chloride; diethyl 2-(n-propyl)-1H-imidazole-4,5-dicarboxylate; In tetrahydrofuran; toluene; for 6.5h; Inert atmosphere; Cooling with ice;
With hydrogenchloride; In tetrahydrofuran; water; toluene; pH=7;
|
|
|
In tetrahydrofuran; at 60 ℃; for 2h;
|
4.81 g |
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- 74-87-3
methylene chloride
-
- 144689-94-1
diethyl 2-(n-propyl)-1H-imidazole-4,5-dicarboxylate
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- 144689-93-0
ethyl 4-(2-hydroxypropan-2-yl)-2-propyl-1H-imidazole-5-carboxylate
Conditions
| Conditions |
Yield |
|
methylene chloride; With magnesium; In tetrahydrofuran; for 0.5h; Reflux;
diethyl 2-(n-propyl)-1H-imidazole-4,5-dicarboxylate; In tetrahydrofuran; at 30 ℃; for 2.5h; Solvent; Temperature;
|
80% |
|
methylene chloride; With magnesium; at 55 - 60 ℃; for 1h; Inert atmosphere;
diethyl 2-(n-propyl)-1H-imidazole-4,5-dicarboxylate; at 0 ℃; for 8h;
|
|
144689-93-0 Upstream products
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75-16-1
methylmagnesium bromide
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144689-94-1
diethyl 2-(n-propyl)-1H-imidazole-4,5-dicarboxylate
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58954-23-7
2-propyl-1H-imidazole-4,5-dicarboxylic acid
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51802-42-7
2-propylimidazole-4,5-dicarbonitrile
144689-93-0 Downstream products
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172875-59-1
ethyl 4-(1-hydroxy-1-methylethyl)-2-propyl-1-[2'-(2-triphenylmethyl-2H-tetrazol-5-yl)biphenyl-4-yl]methyl-1H-imidazole-5-carboxylate
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144690-96-0
1-[{2'-cyanobiphenyl-4-yl}methyl]-4-(1-hydroxy-1-methylethyl)-2-propylimidazol-5-carboxylic acid ethyl ester
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144690-33-5
ethyl 4-(2-hydroxypropan-2-yl)-2-propyl-1-({2'-[1-(triphenylmethyl)-1H-1,2,3,4-tetrazol-5-yl]-[1,1'-biphenyl]-4-yl}methyl)-1H-imidazole-5-carboxylate
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144689-63-4
olmesartan
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