What is the L-Phenylalanine?

L-Phenylalanine is white crystalline powder, while it's Molecular Formula is C9H11NO2. white crystalline powder L-phenylalanine is an amino acid used as a skin-conditioning agent. It has greater use in hair care than in skin care products.

What is the CAS number for L-Phenylalanine?

The CAS number of L-Phenylalanine is 63-91-2.

What is L-Phenylalanine (63-91-2) used for?

Phenylalanie is an essential amino acid and it is the precursor of the amino acid tyrosine. The body cannot make phenylalanie but it needs phenylalanie to produce proteins. Thus, human needs to obtain phenylalanie from food. 3 forms of phenylalanie are found in the nature: D-phenylalanine, L-phenylalanine, and DL-phenylalanine. Among these three forms, L-phenylalanine is the natural form found in most foods that containing proteins, including beef, poultry, pork, fish, milk, yogurt, eggs, cheeses, soy products, and certain nuts and seeds. The form of phenylalanine determines its application. It is suggested that L-phenylalanine can strengthen the effect of UVA radiation for people with vitiligo, in which L-phenylalanine may lead to darkening or repigmentation of the white patches, particularly on the face. The neurotransmitters L-phenylalanine affects help reduce hunger, improve memory, lessen the symptoms of ADHD and Parkinson's disease, and ease chronic pain, according to the UMMC research. Thus, L-phenylalanine is used in the manufacture of food and drink products and sold as a nutritional supplement for its reputed analgesic and antidepressant effects. L-phenylalanine is also suggested as an intermediate for anti-cancer drugs. A few small studies showed promise using L-Phenylalanine to manage alcohol withdrawal and ease PMS symptoms. It is also used in artificial sweeteners such as aspartame.InChI:InChI:1S/C9H11NO2/c10-8(9(11)12)6-7-4-2-1-3-5-7/h1-5,8H,6,10H2,(H,11,12)

What is the L-Phenylalanine?

L-Phenylalanine is white crystalline powder, while it's Molecular Formula is C9H11NO2. white crystalline powder L-phenylalanine is an amino acid used as a skin-conditioning agent. It has greater use in hair care than in skin care products.

What is the CAS number for L-Phenylalanine?

The CAS number of L-Phenylalanine is 63-91-2.

What is L-Phenylalanine (63-91-2) used for?

Phenylalanie is an essential amino acid and it is the precursor of the amino acid tyrosine. The body cannot make phenylalanie but it needs phenylalanie to produce proteins. Thus, human needs to obtain phenylalanie from food. 3 forms of phenylalanie are found in the nature: D-phenylalanine, L-phenylalanine, and DL-phenylalanine. Among these three forms, L-phenylalanine is the natural form found in most foods that containing proteins, including beef, poultry, pork, fish, milk, yogurt, eggs, cheeses, soy products, and certain nuts and seeds. The form of phenylalanine determines its application. It is suggested that L-phenylalanine can strengthen the effect of UVA radiation for people with vitiligo, in which L-phenylalanine may lead to darkening or repigmentation of the white patches, particularly on the face. The neurotransmitters L-phenylalanine affects help reduce hunger, improve memory, lessen the symptoms of ADHD and Parkinson's disease, and ease chronic pain, according to the UMMC research. Thus, L-phenylalanine is used in the manufacture of food and drink products and sold as a nutritional supplement for its reputed analgesic and antidepressant effects. L-phenylalanine is also suggested as an intermediate for anti-cancer drugs. A few small studies showed promise using L-Phenylalanine to manage alcohol withdrawal and ease PMS symptoms. It is also used in artificial sweeteners such as aspartame.InChI:InChI:1S/C9H11NO2/c10-8(9(11)12)6-7-4-2-1-3-5-7/h1-5,8H,6,10H2,(H,11,12)

Product classification

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L-phenylalanine

Chemical raw materials, non-pharmaceuticals.
Product Name: L-phenylalanine
CasNo: 63-91-2
Purity:
Appearance: white crystalline powder

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CasNo： 63-91-2

Molecular Formula： C₉H₁₁NO₂

Appearance： white crystalline powder

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Molecular Formula:C9H11NO2
Molecular Weight:165.192
Appearance/Colour:white crystalline powder
Vapor Pressure:7.09E-05mmHg at 25°C
Melting Point:270-275 °C (dec.)(lit.)
Refractive Index:-34 ° (C=2, H2O)
Boiling Point:307.5 °C at 760 mmHg
PKA:2.2(at 25℃)
Flash Point:139.8 °C
PSA：63.32000
Density:1.201 g/cm³
LogP:1.34130
IDLH:1432
IDLH:10488
IDLH:3726

L-Phenylalanine(Cas 63-91-2) Usage

Preparation	From PTS-negative Escherichia coli bioengineered strains.
Synthesis Reference(s)	Canadian Journal of Chemistry, 29, p. 427, 1951 DOI: 10.1139/v51-051The Journal of Organic Chemistry, 30, p. 3414, 1965 DOI: 10.1021/jo01021a035Tetrahedron Letters, 26, p. 2449, 1985 DOI: 10.1016/S0040-4039(00)94850-0
Air & Water Reactions	Water soluble. Aqueous solutions are weak acids.
Reactivity Profile	L-Phenylalanine may be light sensitive. Act as weak acids in solution.
Health Hazard	ACUTE/CHRONIC HAZARDS: When heated to decomposition L-Phenylalanine emits toxic fumes of nitrogen oxides.
Fire Hazard	Flash point data for L-Phenylalanine are not available; however, L-Phenylalanine is probably combustible.
Biochem/physiol Actions	L-Phenylalanine is an essential amino acid. It is significantly involved in the synthesis of neurotransmitters such as dopamine, epinephrine, norepinephrine, l-DOPA (Dihydroxyphenylalanine), melanin and thyroxine. L-Phenylalanine metabolism also results in phenylethylamine, that brings about effect of a stimulant in the brain and enhances mood.
Purification Methods	Likely impurities are leucine, valine, methionine and tyrosine. Crystallise L-phenylalanine from water by adding 4volumes of EtOH. Dry it in vacuo over P2O5. Also crystallise it from saturated refluxing aqueous solutions at neutral pH, or 1:1 (v/v) EtOH/water solution, or conc HCl. It sublimes at 176-184o/0.3mm with 98.7% recovery and unracemised [Gross & Gradsky J Am Chem Soc 77 1678 1955]. [Greenstein & Winitz The Chemistry of the Amino Acids J. Wiley, Vol 3 pp 2156-2175 1961, Beilstein 14 IV 1552.]
Precursor of Biochemical Pathways	Phenylalanine serves as a precursor for the phenylpropanoid pathway and is essential for the synthesis of melanin, dopamine, noradrenaline (norepinephrine), and thyroxine.
Marker of Disease Severity in COVID-19	Serum levels of phenylalanine have been associated with increased inflammation, higher SOFA scores, ICU admission, and mortality rates among COVID-19 patients. Lower serum phenylalanine levels were observed in mild cases compared to moderate and severe cases.
Role in Age-Related Cardiac Dysfunction	Elevated plasma levels of phenylalanine are associated with age-related cardiac dysfunction. Aging leads to increased plasma phenylalanine levels, which may promote cardiac dysfunction. Pharmacological restoration of phenylalanine catabolism has been suggested as a potential therapeutic strategy for age-associated cardiac impairment.
Personal Health Monitoring During Exercise	Phenylalanine fluctuations induced by protein intake during exercise can be tracked, and sweat-blood phenylalanine levels can be analyzed for personal health monitoring. Sweat phenylalanine levels correlate with blood phenylalanine levels and can be used to assess various nutrition and disease statuses, such as phenylketonuria (PKU), muscle protein metabolism during exercise, liver dysfunction in obesity, and viral infection severity.
Associated with Phenylketonuria (PKU)	Phenylalanine metabolism is disrupted in individuals with phenylketonuria (PKU), leading to the accumulation of phenylalanine in the brain, which can cause profound and irreversible mental disability if left untreated.
Definition	ChEBI: The L-enantiomer of phenylalanine.
General Description	Odorless white crystalline powder. Slightly bitter taste. pH (1% aqueous solution) 5.4 to 6.
Who Evaluation	Evaluation year: 2004

InChI:InChI:1S/C9H11NO2/c10-8(9(11)12)6-7-4-2-1-3-5-7/h1-5,8H,6,10H2,(H,11,12)

63-91-2 Relevant articles

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63-91-2 Process route

: 2360-97-6,14235-17-7,14235-18-8,97471-44-8
L-phenylalanine-p-nitroanilide

: 63-91-2,25191-15-5,658-69-5,67675-33-6
L-phenylalanine

: 100-01-6,104810-17-5
4-nitro-aniline

Conditions

Conditions	Yield
With phosphate buffer; chymotrypsine; at 25 ℃; Product distribution; Rate constant; hydrolysis, various substrates under different reaction conditions;

: 17663-35-3,55895-89-1,58848-63-8
p-Nitrophenyl-L-phenylalaninate

: 100-02-7,78813-13-5,89830-32-0
4-nitro-phenol

: 63-91-2,25191-15-5,658-69-5,67675-33-6
L-phenylalanine