What is the Bivalirudin?

Bivalirudin is White powder, while it's Molecular Formula is C98H138N24O33. White powder Anticoagulant; antithrombotic.

What is the CAS number for Bivalirudin?

The CAS number of Bivalirudin is 128270-60-0.

What is Bivalirudin (128270-60-0) used for?

Bivalirudin was launched in New Zealand as an anticoagulant for i.v. treatment ofpatients with unstable angina undergoing percutaneous transluminal coronary angioplasty.Bivalirubin is a synthetic 20 amino acid peptide rationally modeled on hirudin (residues 53-64), the most potent and specific naturally-occuring known inhibitor of thrombin, theenzyme that plays a key role in hemostasis and blood clot formation. This peptide is adirect thrombin inhibitor that maintains the unique bivalent binding properties of hirudin tothe catalytic site and to the fibrin-recognition exosite of the enzyme, so acting directly onthrombin with high affinity and specificity. In vitro studies demonstrated that alpha- andzeta-thrombins, both with the higher fibrinogen-procoagulant activities, were inhibited. Inrats receiving high doses of bivalirudin, the platelet deposition in carotide was reduced by63% compared to controls. The results of clinical studies, conducted only in patientsreceiving concomitant aspirin, suggested that the use of bivalirudin was more efficaciousand more predictable than unfractionated heparin, with fewer bleeding complications.Despite some unresolved developmental issues, the attractive properties of this novelagent could make it a useful alternative to heparin in a variety of coagulation disorders.InChI:InChI=1/C98H138N24O33/c1-5-52(4)82(96(153)122-39-15-23-70(122)92(149)114-60(30-34-79(134)135)85(142)111-59(29-33-78(132)133)86(143)116-64(43-55-24-26-56(123)27-25-55)89(146)118-67(97(154)155)40-51(2)3)119-87(144)61(31-35-80(136)137)112-84(141)58(28-32-77(130)131)113-88(145)63(42-54-18-10-7-11-19-54)117-90(147)66(45-81(138)139)110-76(129)50-107-83(140)65(44-71(100)124)109-75(128)49-106-73(126)47-104-72(125)46-105-74(127)48-108-91(148)68-21-13-38-121(68)95(152)62(20-12-36-103-98(101)102)115-93(150)69-22-14-37-120(69)94(151)57(99)41-53-16-8-6-9-17-53/h6-11,16-19,24-27,51-52,57-70,82,123H,5,12-15,20-23,28-50,99H2,1-4H3,(H2,100,124)(H,104,125)(H,105,127)(H,106,126)(H,107,140)(H,108,148)(H,109,128)(H,110,129)(H,111,142)(H,112,141)(H,113,145)(H,114,149)(H,115,150)(H,116,143)(H,117,147)(H,118,146)(H,119,144)(H,130,131)(H,132,133)(H,134,135)(H,136,137)(H,138,139)(H,154,155)(H4,101,102,103)/t52-,57+,58-,59-,60-,61-,62-,63-,64-,65-,66-,67-,68-,69-,70-,82-/m0/s1

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Bivalirudin

Product Name: Bivalirudin
CasNo: 128270-60-0
Purity:
Appearance: White powder

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CasNo： 128270-60-0

Molecular Formula： C₉₈H₁₃₈N₂₄O₃₃

Appearance： White powder

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Molecular Formula:C98H138N24O33
Molecular Weight:2180.31
Appearance/Colour:White powder
Refractive Index:1.675
PSA：901.57000
Density:1.52 g/cm³
LogP:0.54320

Bivalirudin 128270-60-0 Usage

Bivalirudin is a synthetic peptide that is used as an anticoagulant to prevent harmful blood clots from forming and to reduce blood clotting ability. It is a direct thrombin inhibitor (DTI) that works by binding to the active site of thrombin, preventing it from activating fibrinogen into fibrin. This is a crucial step in the formation of thrombus. Bivalirudin is administered intravenously and is often used in combination with aspirin. Shanghai Wibson Biotechnology Co., Ltd. is a high-tech enterprise that mainly develops and sells pharmaceutical and chemical raw materials and other related products. We have 16 years of experience in R&D and manufacturing, we have rich experience in shipping, many well-known companies have cooperated with us, and are good at shipping various chemical products with us.

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Bivalirudin 128270-60-0 Usage

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