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CasNo: 64963-01-5
Molecular Formula: C29H39N5O7
General Description |
(D-Ala²)-Leu-Enkephalin is a synthetic peptide analog of the naturally occurring enkephalin, a type of endogenous opioid peptide that binds to opioid receptors in the brain. Enkephalins play a role in modulating pain and stress responses in the body. In this analog, the second amino acid in the sequence is modified, replacing glycine with D-alanine, which increases its stability against enzymatic degradation, prolonging its biological activity. Like natural enkephalins, (D-Ala²)-Leu-Enkephalin has potent analgesic effects by mimicking the action of endorphins, and it interacts primarily with delta-opioid receptors. Its structure includes five amino acids: D-alanine, tyrosine, glycine, phenylalanine, and leucine. |
InChI:InChI=1/C29H39N5O7/c1-17(2)13-24(29(40)41)34-28(39)23(15-19-7-5-4-6-8-19)33-25(36)16-31-26(37)18(3)32-27(38)22(30)14-20-9-11-21(35)12-10-20/h4-12,17-18,22-24,35H,13-16,30H2,1-3H3,(H,31,37)(H,32,38)(H,33,36)(H,34,39)(H,40,41)/t18-,22+,23+,24+/m1/s1
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Based on the physicochemical and pharmac...
2>Leu-enkephalin and 2,D-Leu5>Leu-enkep...
An enkephalin derivative, [D-Ala2,Leu5]e...
The use of the dimethylphosphinothioyl (...
H-L-Tyr(Mpt)-D-Ala-Gly-L-Phe-L-Leu-OH
D-Ala2-Leu5-enkephalin
Conditions | Yield |
---|---|
With sodium hydroxide; In methanol; at 0 ℃;
|
94% |
Nα-(tert-butoxycarbonyl)-
D-Ala2-Leu5-enkephalin
Conditions | Yield |
---|---|
With methoxybenzene; trifluoroacetic acid;
|
47% |
Nα-(tert-butoxycarbonyl)-
N-benzyloxycarbonyl-O-benzyl-L-tyrosine
{(R)-2-[(S)-2-Benzyloxycarbonylamino-3-(4-benzyloxy-phenyl)-propionylamino]-propionylamino}-acetic acid methyl ester