What is the Atosiban?

Atosiban is solid, while it's Molecular Formula is C43H67N12O38S2. solid Atosiban has been used:as an oxytocin receptor antagonistin the calcium mobilization assay for Z factor determination in uterine myometrium (UT-myo cells) and as a therapeutic agent to inhibit preterm laborto inhibit the activation of oxytocin-receptor-expressing neurons in the parabrachial nucleus of mice (OxtrPBN)

What is the CAS number for Atosiban?

The CAS number of Atosiban is 90779-69-4.

What is Atosiban (90779-69-4) used for?

Atosiban was introduced in the UK as an injectable inhibitor of preterm labor, a majorcause of infant morbidity and mortality. This peptidic oxytocin analog is an antagonist ofthe vasopressin V1a receptor and of the oxytocin receptor which is found in dramaticallyincreased concentration in the uterine myometrium of pregnant women near term. Itcompetitively inhibited contractions in the pregnant guinea pig uterus induced by oxytocinand vasopressin. In a multicenter, double-blind, placebo-controlled trial, treatment withatosiban caused pregnancy prolongation for up to 7 days in women with more than 28weeks of gestation. In a comparative clinical trial, atosiban showed a comparable tocolyticaction (uterine relaxant) to ritodrine but the former was significantly better tolerated,especially with regards to maternal cardiovascular side effects. In healthy volunteers,plasma levels of atosiban decreased bi-exponentially with an initial and a terminal half-life of 21 min and 1.7h respectively.InChI:InChI=1/C43H67N11O12S2/c1-5-23(3)35-41(63)53-36(24(4)55)42(64)50-29(20-32(45)56)38(60)51-30(43(65)54-17-8-10-31(54)40(62)49-27(9-7-16-44)37(59)47-21-33(46)57)22-68-67-18-15-34(58)48-28(39(61)52-35)19-25-11-13-26(14-12-25)66-6-2/h11-14,23-24,27-31,35-36,55H,5-10,15-22,44H2,1-4H3,(H2,45,56)(H2,46,57)(H,47,59)(H,48,58)(H,49,62)(H,50,64)(H,51,60)(H,52,61)(H,53,63)/t23-,24+,27-,28+,29-,30-,31-,35-,36?/m0/s1

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Atosiban

Product Name: Atosiban
CasNo: 90779-69-4
Purity:
Appearance: solid

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CasNo： 90779-69-4

Molecular Formula： C₄₃H₆₇N₁₂O₃₈S₂

Appearance： solid

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Molecular Formula:C43H67N12O38S2
Molecular Weight:994.19
Appearance/Colour:solid
Vapor Pressure:0mmHg at 25°C
Refractive Index:1.549
Boiling Point:1469 °C at 760 mmHg
PKA:12.81±0.70(Predicted)
Flash Point:842.2 °C
PSA：416.27000
Density:1.254 g/cm³
LogP:1.42000

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Atosiban

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