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CasNo: 16830-15-2
Molecular Formula: C48H78O19
Appearance: powder
Description |
Asiaticoside (AS) is a triterpenoid compound found in Centella asiatica, a medicinal herb known for its skin-repairing and collagen-boosting properties. With a molecular formula of C48H78O19 and a molecular weight of 959.12, Asiaticoside promotes wound healing by stimulating collagen biosynthesis and has strong antioxidant properties, which accelerate skin regeneration, improve elasticity, and reduce UV-induced pigmentation. It also exhibits anti-inflammatory effects and is used in treatments for burns, ulcers, and skin conditions like psoriasis and lupus. In addition to its dermatological applications, Asiaticoside has neuroprotective properties, helping to attenuate neuronal damage caused by β-amyloid exposure and glutamate-induced excitotoxicity. It reduces calcium influx and modulates apoptotic proteins, potentially making it useful in treating neurological conditions. This compound, along with madecassoside, is widely used in traditional medicine systems like Ayurveda and Chinese medicine for its neuroprotective, cardioprotective, anti-arthritic, and immunomodulatory effects. |
Safety Profile |
Questionable carcinogen withexperimental tumorigenic data. When heated todecomposition it emits acrid smoke and fumes. Promoteshealing of wounds. |
Referances |
Therapeutic properties and pharmacological activities of asiaticoside and madecassoside: A review , Shinjini Bandopadhyay, Sujata Mandal, Mimosa Ghorai, Niraj Kumar Jha, Manoj Kumar, Radha, Arabinda Ghosh, Jarosław Proćków, José M. Pérez de la Lastra, Abhijit Dey , Journal of Cellular and Molecular Medicine, Volume27, Issue5 March 2023 Pages 593-608 Asiaticoside and madecassoside are also used extensively in treating skin abnormalities, burn injuries, ischaemia, ulcers, asthma, lupus, psoriasis and scleroderma. Besides medicinal applications, these phytocompounds are considered cosmetically beneficial for their role in anti-ageing, skin hydration, collagen synthesis, UV protection and curing scars. Existing reports and experimental studies on these compounds between 2005 and 2022 have been selectively reviewed in this article to provide a comprehensive overview of the numerous therapeutic advantages of asiaticoside and madecassoside and their potential roles in the medical future. |
InChI:InChI=1/C48H78O16/c1-22-12-17-48(19-18-46(7)25(30(48)23(22)2)10-11-29-45(6)15-9-14-44(4,5)28(45)13-16-47(29,46)8)43(58)64-42-37(56)34(53)32(51)27(62-42)21-59-40-38(57)35(54)39(26(20-49)61-40)63-41-36(55)33(52)31(50)24(3)60-41/h10,22-24,26-42,49-57H,9,11-21H2,1-8H3/t22-,23+,24+,26-,27-,28+,29-,30+,31+,32-,33-,34+,35-,36-,37-,38-,39-,40-,41+,42+,45+,46-,47-,48+/m1/s1
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asiatic acid
methyl 2α-hydroxy-3β,23-isopropylidenedioxyurs-12-ene-28-oate
2α,3β,24-triacetyloxy-urs-12-en-28-oic acid