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CasNo: 113-79-1
Molecular Formula: C46H65N15O12S2
Appearance: White powder
Indications |
Argipressin AOP is indicated in adults for the treatment of diabetes insipidus, when this is not of nephrogenic origin, and control of bleeding from oesophageal varices. |
Hazard |
A poison. |
Biochem/physiol Actions |
Actions on vascular smooth muscle V1 receptors cause peripheral vasoconstriction and increase systemic vascular resistance and blood pressure. Less potent actions on V2 receptors in the kidneys cause an antidiuretic effect by promoting water reabsorption by the renal tubules. |
Safety Profile |
Although generally safe, vasopressin may worsen cardiac output in patients with impaired cardiac function. |
Brand name |
Pitressin (Parke-Davis). |
General Description |
Argipressin, also known as arginine vasopressin (AVP) or vasopressin, is a hormone that regulates extracellular fluid volume and has antidiuretic properties. |
InChI:InChI=1/C46H65N15O12S2.C2H4O2/c47-27-22-74-75-23-33(45(73)61-17-5-9-34(61)44(72)56-28(8-4-16-53-46(51)52)39(67)54-21-37(50)65)60-43(71)32(20-36(49)64)59-40(68)29(14-15-35(48)63)55-41(69)31(18-24-6-2-1-3-7-24)58-42(70)30(57-38(27)66)19-25-10-12-26(62)13-11-25;1-2(3)4/h1-3,6-7,10-13,27-34,62H,4-5,8-9,14-23,47H2,(H2,48,63)(H2,49,64)(H2,50,65)(H,54,67)(H,55,69)(H,56,72)(H,57,66)(H,58,70)(H,59,68)(H,60,71)(H4,51,52,53);1H3,(H,3,4)/t27-,28-,29-,30-,31-,32-,33-,34-;/m0./s1
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Cys-Tyr-Phe-Gln-Asn-Cys-Pro-Arg-Gly-NH2
Captopril disulfide
Cys-Tyr-Phe-Gln-Asn-Cys-Pro-Arg-Gly-NH2
captopril
Conditions | Yield |
---|---|
In water; at 25 ℃; for 5h; Equilibrium constant; pH 7.0;
|
C55H80N16O15S3
C55H80N16O15S3
Cys-Tyr-Phe-Gln-Asn-Cys-Pro-Arg-Gly-NH2
captopril
Conditions | Yield |
---|---|
In water; at 25 ℃; for 5h; Rate constant; Equilibrium constant; pH 7.0;
|
benzyloxycarbonyl-S-(2,4,6-trimethylbenzyl)-L-cysteinyl-O-tert-butyl-L-tyrosyl-L-phenylalanyl-L-glutaminyl-L-asparaginyl-S-(2,4,6-trimethylbenzyl)-L-cysteinyl-L-prolyl-NG-p-toluenesulfonyl-L-arginyl-glycine amide
Z-Cys(Bzl)-Tyr(Bzl)-Phe-Gln-Asn-Cys(Bzl)-Pro-Arg(Tos)-Gly-NH2
Cys-Tyr-Phe-Gln-Asn-Cys-Pro-Arg-Gly-NH2
Captopril disulfide
L-cystine
Cys-Tyr-Phe-Gln-Asn-Cys-Pro-Arg-Gly-NH2
Oxidized glutathione
H-Cys-Try(I2)-Phe-Gln-Asn-Cys-Pro-Arg-Gly-NH2 disulphide