2-Ethylhexyl phthalate

Medical Uses

DEHP is used in medical devices, particularly in respiratory assistance devices.^[2]

Health Risks

DEHP has been widely used as a plasticizer in various consumer products since the mid-20th century. It's potential health risks have led to regulatory scrutiny and risk assessments by organizations such as the European Food Safety Authority (EFSA). DEHP exposure can occur through various routes, including dietary intake, inhalation of contaminated air, and dermal contact with consumer products. DEHP contamination in aquatic environments can affect aquatic organisms, leading to potential ecological consequences.^[4]

DEHP is considered an endocrine disruptor, affecting hormone systems, especially related to reproduction and development. It has been linked to several health risks, including:

Reproductive Issues: DEHP can negatively impact male fertility by affecting sperm production and testosterone levels. It may also interfere with female reproductive health.

Developmental Concerns: Pregnant women exposed to DEHP may experience disrupted fetal development, leading to birth defects or developmental disorders in offspring. Children are particularly vulnerable to DEHP exposure.

Thyroid Disruption: DEHP and its metabolite, Mono(2-ethylhexyl) phthalate (MEHP), have been associated with thyroid dysfunction and tissue damage.

Cancer Risk: Animal studies suggest DEHP may contribute to liver tumors and other cancers, although the evidence in humans is still under review.

Toxicity to Fetuses: Exposure during pregnancy is associated with long-term health effects on the fetus, potentially leading to chronic diseases in adulthood.